vasopresin

Vasopresin neboli antidiuretický hormon (ADH) je peptidický hormon o délce 9 aminokyselin, takže se jedná o oligopeptid. V nejběžnější formě má sekvenci Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-amid (ale vyskytuje se i forma s lysinem na pozici 8 místo argininu). Název antidiuretický hormon je odvozen ze skutečnosti, že působí proti diurézi, tedy tvorbě moči v ledvinách.

Vazopresin (a příbuzný oxytocin) se vyskytují zejména u obratlovců a zřejmě vznikly jistou genovou duplikací. Situaci však komplikuje skutečnost, že i u některých bezobratlých existují peptidy s podobnou strukturou a funkcí, jako vazopresin a oxytocin.

vasopressin

Vasopressin, also known as antidiuretic hormone (ADH), is a neurohypophysial hormone found in most mammals.

Vasopressin is responsible for regulating the body retention of water by acting to increase water absorption in the collecting ducts of the kidney nephron. Vasopressin increases water permeability of the kidney collecting duct and distal convoluted tubule by inducing translocation of aquaporin-CD water channels in the kidney nephron collecting duct plasma membrane.

Vasopressin is a peptide hormone that controls the reabsorption of molecules in the tubules of the kidneys by affecting the tissue permeability. It also increases peripheral vascular resistance, which in turn increases arterial blood pressure. It plays a key role in homeostasis, by the regulation of water, glucose, and salts in the blood. It is derived from a preprohormone precursor that is synthesized in the hypothalamus and stored in vesicles at the posterior pituitary. Most of it is stored in the posterior pituitary to be released into the bloodstream.