acetylace

Acetylace je přidání acetylové skupiny, u proteinů se jedná o přidání CH3CO na aminokyselinu lyzin. V případě histonů se jedná o modifikaci regulující genovou expresi. Acetylace probíhá i na proteinech nehistonové povahy jako je strážce genomu- p53 nebo třeba tubulin.

Naproti tomu deacetylace znamená odebrání acetylové skupiny CH3CO z cílového proteinu.

acetylation

Acetylation (or in IUPAC nomenclature ethanoylation) describes a reaction that introduces an acetyl functional group into a chemical compound. (Deacetylation is the removal of the acetyl group.)

Specifically, acetylation refers to that process of introducing an acetyl group (resulting in an acetoxy group) into a compound, to be specific, the substitution of an acetyl group for an active hydrogen atom. A reaction involving the replacement of the hydrogen atom of a hydroxyl group with an acetyl group (CH₃ CO) yields a specific ester, the acetate. Acetic anhydride is commonly used as an acetylating agent reacting with free hydroxyl groups. For example, it is used in the synthesis of aspirin and heroin.