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Postdoctoral Researcher - Cellular and Molecular Immunoregulation

Typ práce: hlavní pracovní poměr

We are seeking a motivated postdoctoral fellow with a background in immunology and cell biology who will join the team of Dr. Jan Frič focused on cell signaling control of innate immune response and inflammatory regulation of hematopoiesis. The Cellular and Molecular Immunology Group is part of Centre for Translational Medicine (CTM) at the International Clinical Research Center of St. Anne´s University Hospital in Brno (FNUSA – ICRC).


The International Clinical Research Center of St. Anne's University Hospital in Brno (FNUSA-ICRC), Czech Republic is a new-generation research center focusing on the pathogenesis of diseases including finding new methods, technologies and medicaments for effective prevention, early diagnostics and individualized treatment. We are a top Central European research center with more than 200 researchers, new technologies and experience in using EU grant support. We focus on research and development mainly in the fields of cardiovascular and neurological diseases. Our partners are world-class research centers and universities. For more reference, you can see our website.

Research focus:

The postdoctoral researcher will develop an independent project in the field of innate immune signaling and inflammatory regulation of hematopoiesis. The postdoctoral researcher will have an opportunity to participate in ongoing grant projects targeting unresolved aspects of pattern recognition receptors signaling in peripheral blood monocytes in context of inflammation and immunosenescence.

The Cellular and Molecular Immunoregulation group (CMI) develops experimental models addressing the role of hematopoietic precursors in orchestrating immune response in tissues (3D models). Furthermore, CMI studies new aspects of pattern recognition receptors signaling pathways. These signaling pathways are main sensors of infection and tissue damage and play the crucial role in control of acute and chronic inflammatory disorders accompanying for example tissue regeneration or aging processes. A better understanding of pattern recognition receptors signaling may lead to new strategies for the therapeutic control of inflammatory disorders.

Our recent publications:

  • EMBO Mol. Med., 2017, doi: 10.15252/emmm.201707698,
  • Mucosal Immunol., 2017, doi:10.1038/mi.2016.52,
  • Cell Rep. 2017, doi: 10.1016/j.celrep.2017.07.063,
  • Front. Immunol. 2017, doi: 10.3389/fimmu.2017.01078 

Starting Date: Immediate (negotiable)

FTE: 1 FTE (full-time assignment), 2 year fixed term contract

 Job Description – you will:

  • Undertake independent research with a mentorship of Principal Investigator
  • Design, perform and analyze experiments and write papers
  • Acquire new technical skills as required by the project
  • Write, edit and submit manuscripts/abstracts detailing the results of the project
  • Supervise students and younger colleagues and assist with writing grant applications
  • Present at conferences and workshops
  • Work with cell cultures and peripheral blood cells from donors and patients; analyze inflammatory signaling processes by cellular and molecular immunology techniques.

Desirable qualifications:

  • Ph.D. in immunology, cell biology, molecular biology or other related field
  • Experience in cellular and molecular immunology including cell culture, signaling, transcriptional regulation and gene expression analysis, cloning and protein assays
  • Experience with flow cytometry and confocal microscopy
  • Well organized, responsible, self-motivated, creative and flexible attitude
  • Positive and team-work personality
  • An interest in biology of myeloid cells and cell signaling, chronic inflammation, immunosenescence or hematopoiesis

We offer:

  • Working in international multidisciplinary team of experts in immunology, stem cells, cell signaling, cell imaging with a strong publication track record and international collaborations
  • Engagement in ambitious projects of basic and clinical immunology
  • Work in an inspiring and highly collaborative environment using state-of-the-art technologies
  • Opportunities for further education and training
  • Competitive salary and fix-term contract for 2 year with possibility of extension

How to apply:

The candidates are invited to send their curriculum vitae, cover letter describing motivation and previous experience and 2 recommendation contacts to jobs.icrc@fnusa.cz until 20th October 2017. For more information mail to Dr. Jan Frič (jan.fric@fnusa.cz) or Ms. Tereza Kejdová (tereza.kejdova@fnusa.cz).



We are pleased to consider all qualified applicants for employment without regard to age, gender, marital status, sexual orientation, race, color, religion, ethnicity, disability, national origin, nationality, political opinion or any other aspect unrelated to work.

By responding to this invitation and/or sending your CV and any other personal materials to St. Anne's University Hospital, you consent to the collection, processing and storage of your personal data in accordance with Act No. 101/2000 Coll., the protection of personal data. You are providing St. Anne's University Hospital with these data solely for the purpose of mediating employment, the period however being no longer than one year from submitting. Should you not reclaim the materials submitted by you, they will be discarded after the period has expired.

Kontaktní osoba:
Dr. Jan Frič



Vloženo: 19.9.2017



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