Nová nano-kapsle lipidů používaná jako nosič kosmetických látek pro zvýšenou účinnost.

Francouzská společnost nabízí novou a exkluzivní technologií zapouzdření pro kosmetické aplikace. Tato technologie je založena na novém a patentovaném procesu přípravy nano-kapslí lipidů. Velkovýroba již byla úspěšně dokončena. Postupy jsou k dispozici. Licenční smlouva je použitelná pro kosmetické aplikace, na výhradní nebo nevýhradní bázi. Licenční smlouva poskytne solidní mezinárodní patentovou ochranu.

Description:
Lipid nanocapsules consist of a liquid oily core which is coated with a tensioactive rigid membrane. They differ from solid lipid nanoparticles which are made with a solid core. The core of the lipid nanocapsule acts as a liquid reservoir for one or more compounds, while the membrane acts as a protective shell. Lipid nanocapsules are a hybrid structure between polymer nanocapsules and liposomes. They represent a new generation of biomimetic carriers which mimic lipoproteins. Their penetration through the human stratum corneum has been evaluated together with the release profile of the encapsulated ingredients. Both can be easily adjusted as needed through specific parameters. Encapsulated active ingredients are well protected until they are released. Several cosmetic compounds can be co-encapsulated in the same lipid nanocapsule. Encapsulated cosmetic compounds have been tested with excellent results (efficacy, safety, consumer acceptance data). Complete regulatory files are available. The proposed lipid nanocapsule technology has been developed for encapsulation of active compounds, either pharmaceutical drugs or cosmetics ingredients. Such lipid nanocapsules can be used as new and efficient delivery systems for topical administration. The preparation process is based on the phase-inversion temperature phenomenon of an emulsion, leading to the formation of lipid nanocapsules. This offer relates to granting exclusive (or non-exclusive) rights to use this new technology for all cosmetics applications.

Innovative Aspects:
Encapsulation with the proposed technology provides :
- Good protection of compounds until release,
- Sustained release of compounds with better bioavailability profile, enhancing efficacy or allowing lower concentrations,
- Ability to cross skin barrier (i.e. stratum corneum) and to deliver compounds to targeted cells in viable epidermis.

The proposed lipid nanocapsules are versatile carrier systems suitable for any type of compounds (lipophilic and hydrophilic).

The preparation process has significant benefits when compared with other more conventional micro/nano encapsulations :
- Low-cost and energy-soft
- Integrity of cosmetic active ingredient preserved
- No organic solvent required
- High encapsulation capacity and yields
- Good control over size of lipid nanocapsules (typically 20 nm to 120 nm)
- Very narrow distribution of sizes
- Robust and easy-to-scale-up process
- Excellent physical and chemical stability

All components of the lipid nanocapsules are approved by the Federal Drug Administration and the National Agency of Drug Security for topical use. The National Agency of Drug Security in France validates the launching of the technology on the European market.
They are all biodegradable, with excellent biocompatibility and skin tolerability.
Encapsulated compounds are well stabilized (long storage shelf life).

Comments:
- Type of partner sought: Cosmetics manufacturer, or manufacturer of active ingredients for cosmetics.
- Specific area of activity of the partner: Cosmetics (skin care, hair care).
- Task to be performed: use of the technology to make, have made, market and sell products containing such technology, and enhancements for all cosmetics applications on a worldwide basis.

(13 FR 35L2 3RSU)