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PhD Student Position

Typ práce: hlavní pracovní poměr

The role of protein friction in the dynamics of cytoskeletal filaments. The cytoskeleton is the intracellular network of dynamical filaments, interconnected and regulated by associated proteins, that both generates intracellular mechanical forces and withstands forces from the outside. One of the canonical force-generating mechanism in cytoskeleton is the assembly and disassembly of cytoskeletal filaments, termed the filament dynamics. Friction limits the force generation in all mechanical systems, but experimental studies of its effect on the mechanics of cytoskeleton have only just begun. How friction affects filament dynamics, remains an open question.

Project:

The project, based on previous results (Lansky, Braun et al. Cell 2015, 160(6): 1159-68 and Braun, Lansky et al. Nat Cell Biol 2011, 13(10): 1259- 64), will be focused on quantitative characterization of the effects of friction-generating cytoskeletal proteins on dynamics of cytoskeletal filaments. The individual proteins will be expressed in a recombinant form, combined with cytoskeletal filaments in vitro and the emergent system will be investigated using a combination of advanced biophysical and biochemical experimental techniques such as single molecule fluorescence microscopy and optical tweezers.

Candidate's profile: Eligible candidates should have a degree in (bio)physics, biology, chemistry or equivalent and should be interested in cross-disciplinary experimental work.

Contact: For application or further information please contact us (see below).

Marcus Braun, PhD BIOCEV Institute of Biotechnology, CAS Průmyslová 595, 25242 Vestec Czech Republic 

Kontaktní osoba:
Marcus Braun or Zdeněk Lánský

E-mail:
braun@mpi-cbg.de, zdenek.lansky@ibt.cas.

WWW:
www.biocev.eu

Vloženo: 9.12.2016

 

OPPI, MPO, EU

CEBIO a I. etapa JVTP

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  • ALIDEA

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